Vitamin K supplements, vitamin K deficiency

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Vitamin K supplements

Consuming 1,000 mcg per day of Vitamin K1 (phylloquinone) supplements for two weeks reduce ucOC levels in women with postmenopausal syndrome. Biochemical markers of the bone formation will be increased as well.

Vitamin K Supplements Benefits

It is reported in Japan that intervention trials in osteoporotic women and hemodialysis patients who consumes a very high dosage (45 mg per day) of menatetrenone, also known as MK-4, have resulted in a great reduction in bone loss rate (34, 35).
Which foods contain MK-4? Diets and foods do not contain MK-4. Instead, we can get MK-4 from vitamin K supplements which contain phylloquinone. It is manufactured in small amounts in the body.

A recent study conducted by seven Japanese has associated MK-4 supplements with reduced fracture incidents and increased BMD. However, this analysis did not include unpublished data reports of MK-4 which has no effect on the risk of fracture. Nevertheless, the analysis reported that taking MK-4 supplements lowered the risk for fractures of hip by 77%, vertebral fractures by as much as 60%, and non-vertebral fractures by 81%. These statistics were very significant.

Six trial individuals were employed to consume 45 mg of MK-4 everyday, whereas one trial individual consumed 15 mg everyday.
To compare the benefits of MK-4 over placebo, daily dosage of 45 mg of MK-4, and placebo, was taken in a recent study of 325 women with postmenopausal syndrome for a period of 3 years.

This study has shown that menatetrenone supplements improved the strength of the bones compared to those consuming placebo. Vitamin K doses used, compared to AI, are approximately 500 times higher in most studies. However, some researchers are not sure of the relation between high dosage of MK-4 and the true effects of vitamin K.

Vitamin K Deficiency

Deficiency in vitamin K causes blood clotting impairment. Laboratory tests are demonstrated to measure the clotting time.
Deficiency in vitamin K symptoms include easy bleeding and bruising that are manifested as bleeding gums, nosebleeds, blood in urine, tarry black stools, blood in stools, or very heavy menstrual bleeding. Vitamin K deficiency in infants can cause life-threatening bleeding in the skull.

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